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CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 105-118 doi: 10.1007/s11684-022-0934-1

Abstract: In this study, OSI induced higher CD47 expression, an important anti-phagocytic immune checkpoint, viaThe combination treatment of OSI and the anti-CD47 antibody exhibited dramatically increasing phagocytosisMeanwhile, combining the anti-CD47 antibody significantly augmented the anticancer effect of OSI in HCC827findings suggest the multidimensional regulation by OSI and encourage the further exploration of combining anti-CD47antibody with OSI as a new strategy to enhance the anticancer efficacy in EGFR-mutant NSCLC with CD47

Keywords： osimertinib     anti-CD47 antibody     combination strategy     ADCP     EGFR    

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Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 139-149 doi: 10.1007/s11684-021-0835-8

Abstract: The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients withmultiple trials have shown that approximately 30% of blinatumomab-relapsed cases are characterized by CD19Blinatumomab and A-319 are CD3/CD19 bispecific antibodies with different molecular sizes and structures, and A-2019 is a novel CD3/CD19/CD20 trispecific antibody with an additional anti-CD20 function.in cells missing CD19, suggesting its potential function against CD19 weak or negative CD20 positive

Keywords： B-cell acute lymphoblastic leukemia     bispecific antibody     trispecific antibody     CD19     CD20    

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CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 204-211 doi: 10.1007/s11684-016-0443-1

Abstract: CD176 could be a promising target for antitumor immunotherapy.A positive clone of CD176 single-chain variable antibody fragment (scFv) was successfully screened fromThe CD176 scFv was expressed in Escherichia coli and purified.Furthermore, the CD176 scFv inhibits the adhesion of CD176+ cancer cells to endothelialThis CD176 scFv provides a basis for future development of recombinant CD176-specific antibodies that

Keywords： CD176     Thomsen-Friedenreich antigen     scFv     cancer     therapy     adhesion     metastasis    

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BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Frontiers of Medicine doi: 10.1007/s11684-023-0996-8

Abstract: OX40 is a costimulatory receptor that is expressed primarily on activated CD4+, CD8+anti-OX40 antibody currently underdose-dependently and significantly depleted regulatory T cells in vitro and in vivo via antibody-dependentantibody showed antitumor efficacy characterized by a hook effect.Furthermore, BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 antibody.

Keywords： BGB-A445     OX40     agonistic antibody     OX40L noncompetitive    

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Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has achieved 40%–50A multi-center phase I/II trial of anti-CD19 CD28z CAR-T (FKC876, ChiCTR1800019661) was conducted.M2-subtype macrophages were significantly involved in both in vivo and in vitro anti-tumor

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment    

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Activation of phagocytosis by immune checkpoint blockade

Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 473-480 doi: 10.1007/s11684-018-0657-5

Abstract: SIRPα), on tumor-associated macrophages (TAMs) and its cognate ligand cluster of differentiation 47(CD47) on tumor cells in the tumor microenvironment.the corresponding therapies may also stimulate macrophages for phagocytosis and thereby provide extra anti-tumor

Keywords： CD47     PD-1     PD-L1     immunotherapy     TAM     phagocytosis     macrophage    

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Preparation, identification, and clinical application of anti-HBs monoclonal antibody that binds both

Fanghe LI BM , Chunyan ZHANG MS , Jinghua LIU MS , Xiaoyan ZHANG MS , Bing YAN , Bo ZHANG MS , Yongguo HUANG MS , Jingsong GONG BM , Yan CHEN BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 277-283 doi: 10.1007/s11684-009-0047-0

Abstract: technique and indirect enzyme-linked immunosorbent assay (ELISA), a hybridoma cell line strain secreting anti-HBsmonoclonal antibody (mAb) (defined G6 mAb) was obtained.Antibody titers in the culture supernatant and ascites were 2.048×10 and 4.096×10, respectivelyBy applying the anti-HBs G6 mAb and horseradish peroxidase (HRP)-labeled goat anti-HBs antibody, we developed

Keywords： hepatitis B virus     gene variation     hepatitis B surface antigen     immune escape     enzyme-linked immunosorbent assay    

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Electrocatalytic debromination of BDE-47 at palladized graphene electrode

Hongtao YU, Bin MA, Shuo CHEN, Qian ZHAO, Xie QUAN, Shahzad AFZAL

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2,   Pages 180-187 doi: 10.1007/s11783-013-0552-x

Abstract: The debromination ability of Ti/Gr/Pd electrodes was investigated using BDE-47 as a target pollutantThe results indicated that the BDE-47 degradation rates on Ti/Gr/Pd electrodes increased with the negativeAlmost all of the BDE-47 was removed in the debromination reaction on the Ti/Gr/Pd electrode at -0.5V, the current efficiency at -0.3 V was higher, because the electrical current acted mostly on BDE-47

Keywords： graphene     palladium     debromination     BDE-47    

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Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomized placebo-controlled trials

Ting Liu, Faping Wang, Geng Wang, Hui Mao

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 340-349 doi: 10.1007/s11684-017-0565-0

Abstract:

Benralizumab is a monoclonal antibody that targets interleukin-5 receptor α to deplete blood

Keywords： benralizumab     anti-interleukin-5     monoclonal antibody     eosinophilic asthma     meta-analysis    

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Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 608-620 doi: 10.1007/s11684-021-0836-7

Abstract: Two leukemic myeloblast populations (CD34 CD117 and CD34 CD117 ) were previously identified in t(8;21Here, we examined the impact of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression on t(8;The mRNA expression levels of CD34 CD117 -associated genes ( , , and ) and CD34 CD117 -associated genesUnivariate analysis revealed that CD19, CD34 CD117 proportion, mutation, minimal residual diseaseIdentifying the clinical relevance of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression may

Keywords： t(8     21)(q22     q22) AML     CD34+CD117dim/ CD34+CD117bri cell population    

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Current State of Monoclonal Antibody Therapy for Allergic Diseases Review

Yan Chen, Wei Wang, Huihui Yuan, Yan Li, Zhe Lv, Ye Cui, Jie Liu, Sun Ying

Engineering 2021, Volume 7, Issue 11,   Pages 1552-1556 doi: 10.1016/j.eng.2020.06.029

Abstract:

Allergic disease is one of the most common chronic diseases, which can affect both children and adults, be often caused by allergen-induced unfavorable immune responses, and initiate various symptoms in different organs, including up-/low-airways and skin, such as asthma, atopic dermatitis, and rhinosinusitis. With increasing prevalence of allergic disease worldwide and their impact on the quality of life, new biological therapeutic approaches for these disorders become hot areas of intensive research. Multiple factors are involved and play important role in the pathogenesis of allergic disease, which can promote or trigger T helper 2 (Th2)-type immune responses, leading to production of the type 2 cytokines and immunoglobulin E (IgE)，the two critical events in the allergic diseases. Using monoclonal antibodies to target these molecules, therefore, might provide possible benefits for the patients suffered from these diseases. Apart of those having approved biologics for allergic diseases, some potential targets such as epithelial-derived alarmins thymic stromal lymphopoietin (TSLP) and interleukin 33 (IL-33) have been also described and proposed to develop monoclonal antibodies against either these cytokines, their receptors, or both. These new and potential targets have substantially enriched the therapeutic opportunities in the field of allergic diseases. The present review aims to briefly outline the role of monoclonal antibodies targeting the cytokines and immunoglobulin involved in the development of allergic diseases, and to discuss the clinical effects of these antibodies.

Keywords： Allergic disease     Monoclonal antibody     Anti-IgE     Cytokines     Clinical trials    

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Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation

Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2,   Pages 226-238 doi: 10.1007/s11783-013-0582-4

Abstract: in low-Cd accumulation cultivars and high-Cd accumulation cultivars of pakchoi ( L.).low-Cd cultivars.The high-Cd cultivars had significantly higher leaf and stem Cd concentrations than the low-Cd cultivarsthan high-Cd cultivars, leaf vacuole sequestrated higher proportions of Cd.Cd in the form of pectate/protein complexes (extracted by 1 mol·L NaCl) played a decisive role in Cd

Keywords： cadmium (Cd)     low-Cd cultivar     pakchoi (Brassica chinensis L.)    

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Enhanced debromination of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) by zero-valent zinc with ascorbic

Chaojin Jiang, Xiaoqian Jiang, Lixun Zhang, Yuntao Guan

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 3, doi: 10.1007/s11783-020-1224-2

Abstract: Highly efficient debromination of BDE-47 was achieved in the ZVZ/AA system.BDE-47 debromination by the ZVZ/AA can be applied to a wide range of pH.Reduction mechanism of BDE-47 debromination by the ZVZ/AA system was proposed.acid (ZVZ/AA) was developed and applied to debrominate the 2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47), which achieved high conversion and rapid debromination of BDE-47 to less- or non-toxic forms.

Keywords： 2     2′     4     4′-tetrabromodiphenyl ether (BDE-47)     Ascorbic acid     Reductive debromination     Zero-valent zinc    

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Cultivars and oil extraction techniques affect Cd/Pb contents and health risks in oil of rapeseed grownon Cd/Pb-contaminated farmland

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 7, doi: 10.1007/s11783-023-1687-z

Abstract:

● Organic solvent extracted fewer Cd/Pb in rapeseed oil than physical

Keywords： Rapeseed oil     Oil extraction technologies     Human health risk assessment     Cd/Pb-contaminated farmland    

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Celecoxib in combination with retinoid CD437 inhibits melanoma A375 cell

Jianwen REN, Zhenhui PENG, Birong GUO, Min PAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 108-112 doi: 10.1007/s11684-009-0015-8

Abstract: of celecoxib, synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid (CD437dimethylthiazol-2-yl)-2,5-di-phenyltetrazoliumbromide assay (MTT assay) was applied to determine the anti-proliferativeCelecoxib in combination with CD437 could significantly enhance the effects of inhibiting proliferationCD437 could inhibit the growth of human malignant melanoma A375 cells by inducing apoptosis and G /GCelecoxib exhibited additive effects with CD437 on retarding the growth and inducing apoptosis of human

Keywords： celecoxib     CD437     melanoma A375 cell     apoptosis     cycle arrest    

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Title Author Date Type Operation

CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer

Journal Article

Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific

Journal Article

CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Journal Article

BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Journal Article

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19

Journal Article

Activation of phagocytosis by immune checkpoint blockade

Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung

Journal Article

Preparation, identification, and clinical application of anti-HBs monoclonal antibody that binds both

Fanghe LI BM , Chunyan ZHANG MS , Jinghua LIU MS , Xiaoyan ZHANG MS , Bing YAN , Bo ZHANG MS , Yongguo HUANG MS , Jingsong GONG BM , Yan CHEN BM ,

Journal Article

Electrocatalytic debromination of BDE-47 at palladized graphene electrode

Hongtao YU, Bin MA, Shuo CHEN, Qian ZHAO, Xie QUAN, Shahzad AFZAL

Journal Article

Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomized placebo-controlled trials

Ting Liu, Faping Wang, Geng Wang, Hui Mao

Journal Article

Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Journal Article

Current State of Monoclonal Antibody Therapy for Allergic Diseases

Yan Chen, Wei Wang, Huihui Yuan, Yan Li, Zhe Lv, Ye Cui, Jie Liu, Sun Ying

Journal Article

Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation

Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU

Journal Article

Enhanced debromination of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) by zero-valent zinc with ascorbic

Chaojin Jiang, Xiaoqian Jiang, Lixun Zhang, Yuntao Guan

Journal Article

Cultivars and oil extraction techniques affect Cd/Pb contents and health risks in oil of rapeseed grownon Cd/Pb-contaminated farmland

Journal Article

Celecoxib in combination with retinoid CD437 inhibits melanoma A375 cell

Jianwen REN, Zhenhui PENG, Birong GUO, Min PAN

Journal Article